Cardiovascular Physiology Autonomic Function Laboratory
The global focus of the Cardiovascular Physiology Autonomic Function Laboratory is to examine the adaptive capacity of the circulation.
- Dr. Levine studies the effects of exercise training, bed rest deconditioning, spaceflight, high altitude, aging, and the effects of cardiovascular diseases, such as heart failure.
- By using sophisticated tools to assess cardiovascular structure and function, Dr. Levine and his research team bring "Olympic" and "space age" science to the solution of common clinical problems such as fainting, hypertension, or patients with shortness of breath.
- The Cardiovascular Physiology Autonomic Function Laboratory focuses on measuring how the cardio-respiratory system distributes oxygen from the environment to the muscles.
- Our facility is one of the few labs in the world that can measure the limitations to exercise capacity at every step along the "oxygen cascade" - including the lungs, heart and muscles.
- We use invasive and non-invasive tools to assess cardiovascular structure and function, as well as circulatory control mechanisms.
Interests
The Impact of atrial fibrillation on exercise performance in patients with HFpEF (Heart failure with preserved ejection fraction)
- About half of all elderly patients with a diagnosis of congestive heart failure have seemingly normal systolic function, so called ‘Heart failure with a preserved ejection fraction” or HFpEF.
- A common condition that these patients also have is atrial fibrillation (AF), with approximately two-thirds developing AF over the course of their disease.
- The contribution of Atrial fibrillation to shortness of breath with exertion is unclear. However, we hypothesize that patients with HFpEF and atrial fibrillation have markedly impaired aerobic capacity and exercise hemodynamics when in atrial fibrillation, compared to sinus rhythm.
Mechanisms of Exercise Intolerance in Heart Failure with Preserved Ejection Fraction (HFpEF)
- This multi-factorial condition, also called “diastolic heart failure” is associated with several abnormalities in diastolic function including increased chamber stiffness, impaired relaxation and impaired ventriculo-arterial coupling.
- To date, there is no consensus on the key physiologic pathways that cause this type of heart failure.
- Dr. Levine’s lab seeks to find out what causes exercise intolerance and shortness of breath (dyspnea) on exertion in these patients, and if specific exercise programs (whole body vs. single leg) will result in improved exercise tolerance.
Synchronizing Cardiac Cycle Phase with Foot Strike to Optimize Left Ventricular performance in Patients with Advanced Heart Failure and Cardiac Resynchronization Therapy (CRT)
- Cardiac resynchronization therapy involves the insertion of electrodes in the left and right ventricles of the heart, as well as on occasion the right atrium, to treat heart failure by coordinating the function of the left and right ventricles via a pacemaker. The pacemaker controls the timing of the upper heart chambers (atria) to the lower heart chambers (ventricles)
- The investigators are curious about the effects of gait and cardiac cycle phase synchronization on muscle oxygenation, cardiac function and exercise performance in patients who have advanced heart failure and who have a CRT pacemaker.
- Subjects will walk on a treadmill for several short sessions; some of the sessions will include walking/stepping to an auditory tone. The auditory tone will attempt to synchronize to the patient’s heartbeat.
Safe and Effective Countermeasures to Reduce Intracranial Pressure (ICP) and Ameliorate Visual Impairment in Astronauts;
- Current estimates suggest that up to 60% of astronauts report degraded visual acuity during short and long duration space flights.
- Findings suggest ocular remodeling, which are consistent with signs and some symptoms reported in patients with increased intracranial pressure
- In previous studies performed by Dr. Levine and his research team, we have demonstrated that the use of lower body negative pressure (LBNP) at -20 mmHg for 8 hours/day while in deep down head tilt restored circadian variability in ICP and prevented the expansion or thickening of choroid.
Current Projects
- Synchronizing cardiac cycle phase with Foot Strike to Optimize LV Performance in Patients with Advanced Heart Failure and Cardiac Resynchronization Therapy
- Mechanisms of Exercise Intolerance in Heart Failure with Preserved Ejection Fraction: ‘Precision’ Therapy Based on Patient Specific Pathophysiology
- Efficacy of High Intensity Exercise (HIE) for Increasing Cardiorespiratory Fitness in Patients with Hypertrophic Cardiomyopathy (HCM)
Current Research Opportunities
View our current research opportunities for:
- Synchronizing cardiac cycle phase with foot strike to optimize LV performance in patients with advanced heart failure and cardiac resynchronization therapy (CRT)
- High Intensity Exercise for Increasing Cardiorespiratory Fitness in Patients with Hypertrophic Cardiomyopathy
Media
Dr. Levine explains how his research with astronauts, whose physiology is affected by the lack of gravity, led to research on the circulation of the bed-ridden and elite rowers. He describes how exercise can help aid recovery from disease and the effects of space-flight at the March 2012 meeting, "The Biomedical Basis of Elite Performance," hosted by the Physiological Society, in partnership with the British Pharmacological Society and Wiley-Blackwell, and sponsored by the Gatorade Sports Science Institute.
WATCH NOW:
UTSW collaborates with U.S. Paralympic Swimming on study
WATCH NOW:
The Biomedical Basis of Elite Performance: Ben Levine interview
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Principal Investigators
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Postdoctoral Fellows / Residents
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Staff
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Cardiovascular response to exercise training in the systemic right ventricle of adults with transposition of the great arteries
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Continuous-Flow Circulatory Support
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Effect of pulsatile and nonpulsatile flow on cerebral perfusion in patients with left ventricular assist devices
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Elevated exercise blood pressure in middle-aged women
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Exercise Training for Patients
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Females have a blunted cardiovascular response to intensive endurance training
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Heart rate recovery after maximal exercise is blunted in hypertensive seniors
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Impact of lifelong exercise "dose" on left ventricular compliance and distensibility
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Mechanisms of Chronotropic Incompetence in Heart Failure
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Patients with heart failure
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Restoration of Pulsatile Flow Reduces Sympathetic Nerve Activity
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Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications For Heart Failure Prevention
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Soothing the sleeping giant
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The Cardiovascular Physiology of Sports and Exercise
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The effect of lifelong exercise dose on cardiovascular function during exercise
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The effect of rowing ergometry and resistive exercise on skeletal muscle structure and function during bed rest
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The international POTS registry
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The impact of 2 years of high-intensity exercise training on a model of integrated cardiovascular regulation
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Trimming the fat, do we know where to begin?
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Exercise-Related Acute Cardiovascular Events
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A 20-year evolution of cardiac performance
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Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy
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Effect of acute and chronic xenon inhalation on erythropoietin
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Safety, hemodynamic effects, and detection of acute xenon inhalation
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Impaired oxygen uptake kinetics in heart failure with preserved ejection fraction
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Mechanisms of Left Atrial Enlargement in Obesity
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Plasma matrix metalloproteinases (MMPs) and tissue inhibitors
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Left Atrial Electromechanical Remodeling Following 2 Years of High-Intensity Exercise Training
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Impact of Lifelong Exercise Training Dose on Ventricular Arterial Coupling
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Lower body negative pressure to safely reduce intracranial pressure
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Exercise and non-pharmacological treatment of POTS
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The effect of lifelong exercise frequency on arterial stiffness
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Does High-Intensity Endurance Training Increase the Risk of Atrial Fibrillation?
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Left Ventricular Volume-Time Relation in Patients
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Effects of Sedentary Aging and Lifelong Exercise
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Starling mechanism in patients with heart failure
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Effect of gravity and microgravity on intracranial pressure
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Potential role of endurance training in altering renal sympathetic nerve activity in CKD?
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Lifelong Physical Activity Regardless of Dose Is Not Associated With Myocardial Fibrosis
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Beyond the Bruce Protocol: Advanced Exercise Testing for the Sports Cardiologist
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The effect of 1 year of Alagebrium and moderate-intensity exercise