Open Studies
- DVR
- Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid, and Tau in older Adults (IPAT) Study
Dynamic Vasomotor Reactivity (DVR) in Alzheimer Disease
Study is no longer open for recruiting.
Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid, and Tau in older Adults (IPAT) Study
Study Doctors: Rong Zhang, Ph.D., Wanpen Vongpatanasin, M.D., David Zhu, Ph.D.
The IPAT study aims to see if intensive reduction of systolic blood pressure SBP reduces brain amyloid-beta and tau deposition in older adults who are at risk for dementia. We will measure brain blood flow, brain structure and function, and cognitive functioning – to determine the effects of intensive lowering of blood pressure.
Study Procedures include:
- Medical and family history
- MRI Scans
- PET-CT Scans
- Memory tests
- Non-invasive vascular testing
Basic qualifications:
- Ages of 60- 80
- Close blood relative with dementia OR a subjective memory concern
- Hypertension : Systolic blood pressure greater than 130
- Be able to undergo an MRI scan – no mental implants or claustrophobia
- No sleep apnea, Major neurological disorders, history of stroke, uncontrolled diabetes, or recent heart disease
Take the prescreening questionnaire.
For more information on this study, email Meg McGregor or call the research team at 214-345-4973.